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Anal fissures are small tears in the mucosa that lines the anus, which can cause severe pain and bleeding during and after bowel movements

There have been multiple randomised controlled trials and systematic reviews that have explored this

So, the glucagon like peptide one stimulates insulin secretion and it inhibits glucagon

Even companies like Amgen and Novartis, still in early or limited stages in this space, are investing heavily in metabolic disease pipelines, signaling that the race for dominance in obesity and diabetes therapeutics is far from over and will only intensify as global prevalence of these conditions continues to rise