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In Diverse Therapeutic Strategies Targeting TMAO, we curated the most pertinent preclinical and in vitro studies on TMAO, emphasizing findings associated with TMAO-induced cell death to deliver a thorough summary of its role in the development and progression of diseases along the gut-organ (lung, pancreas, heart, kidney, and brain) axis

5.10 Hyperammonemia and Encephalopathy Associated with Concomitant Topiramate Use Concomitant administration of topiramate and valproate has been associated with hyperammonemia with or without encephalopathy in patients who have tolerated either drug alone