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While these findings are well-documented in laboratory research, ongoing studies continue to explore its benefits in human biology

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Ipamorelin acts synergistically when applied during a native GHRH (growth-hormone releasing hormone) pulse or when coadministered with GHRH or a GHRH analog such as Sermorelin or GRF 1-29 (growth releasing factor, aminos 1-29).[1] The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, while GHRH increases the number of somatotropes releasing GH.[1,2] There is also a secondary effect of neuronal excitation in the hypothalamus caused by ipamorelin, which lasts for approximately 3 hours after application, similar to GHRP-2 and GHRP-6

Trinucleotide repeat expansion in the genes (CACNA1D and CACNA1A) encoding Ca v 1.3 (L-type) and Ca v 2.1 (P/Q type), respectively, has been identified in a subgroup of patients with type 2 diabetes