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Coniferyl ferulate is a potent inhibitor of glutathione S-transferase ( GST ) ( IC = 0.3 M), which downregulates 50 P-gp expression, induces apoptosis in B-MD-C1 (ADR+/+) cells, and reverses multidrug resistance

This promotes NADPH oxidase-derived ROS, which activates the TGF-/Smad3 signaling pathway, ultimately leading to renal interstitial fibrosis (Wang H

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So, for decades, companies have been putting them into skin care products and dietary supplements you can buy over the counter