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9 Roadmap & research priorities (short-term and long-term) We propose the following prioritized roadmap to guide future progress: (1) Prioritize multi-omics data standardization and integration

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They can be caused by hormonal adaptations, not just a stretched sleeve

To identify uncharacterized factors that control aging and proteostasis, we screened our published transcriptomic profiles (19) for DNA sequences with unknown function that were upregulated in conditions of enhanced protein breakdown (e.g., during fasting), but not when proteolysis was blocked by inhibition of FoxOs (19)