GLP-1 medications: Increase insulin secretion Decrease glucagon release Slow gastric emptying Reduce appetite and hunger signaling Act on receptors in the central nervous system GLP-1 receptor activity in the brain, pancreas, liver, stomach, and adipose tissue, reinforce that these medications affect more than weight alone
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GLP-1 has been reported to improve glucose-dependent insulin action through the G-protein-coupled receptor, GLP-1R (Drucker and Nauck, 2006)