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Epstein ACR, Gleadle JM, McNeill LA, Hewitson KS, ORourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ (2001) C

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Our ancestors practiced fasting during periods of food scarcity, but they also practiced intermittent fasting during periods of abundance, as the food they consumed was much more nutrient-dense than what we consume today, meaning it sustained them for substantially longer periods than the carb-rich meals we typically eat

Prospective studies with larger samples and mechanistic insights are warranted to validate these findings and explore their clinical translation in the management of diabetes-associated dry eye disease