As the liver plays key roles in inflammatory responses, substance metabolism, immune regulation, and excretion [11], it acts both as a target of injury and an "amplifier" of systemic inflammation in the process of host response failure and multi-organ damage
[80] The trial reported cumulative occurrence of major adverse cardiovascular events, a primary end-point event of the trial, for 569 of the 8803 patients in the semaglutide group, which were 6.5% of the participants, and for 701 of the 8801 patients in the placebo group, which were 8% of the participants, showing relative 18.8% less major adverse cardiovascular events, such as death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke, occurring for participants who had received semaglutide in the trial relative to those who had received placebo over the course of around 48 months, or 34.213.7 months, which was the mean (SD) total duration of the participants in either group's exposure to the placebo or semaglutide during the trial
That means its intended for long-term (even life-long) use
Tendon and Ligament Research Sports science and orthopedic research laboratories frequently investigate tendon and ligament biology because these tissues have relatively limited blood supply and complex healing mechanisms
