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The landscape of heart failure (HF) management is evolving alongside a deeper understanding of how metabolic dysfunction drives cardiac pathology and the progression of HF, particularly in phenotypes like HF with preserved ejection fraction (HFpEF) associated with obesity
The pernicious anemias result from impaired DNA synthesis due to a block in purine and thymidine biosynthesis
Exercise improves insulin sensitivity, preserves lean muscle mass during weight loss, and provides cardiovascular benefits independent of weight reduction
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