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Notwithstanding about the promising mechanisms of action, translation to patients is limited by bioavailability and pharmacokinetic issues, inter-subject variability and possible interactions with other chemotherapeutic agents or endocrine therapies highlighting the need for well-conducted randomised controlled trials and PKPD studies (248)

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Apples and Pears Both apples and pears provide a meaningful amount of fibre particularly pectin, which contributes to the feeling of fullness

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