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The relevance of this observation extends to the wider family of GPCRs, with individual effects almost certainly receptor-specific, as both -arrestin-biased 54 and G protein-biased 55 ligands have proved effective for individual receptors in preclinical studies

These findings support the continued use of GLP-1 receptor agonists for approved metabolic indications, while acknowledging that the certainty of evidence varies by cancer site

for Trulicity (dulaglutide) and Mounjaro (tirzepatide), it's 3 days