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Contraindications: Unexplained vaginal bleeding Known or suspected breast cancer or estrogen-dependent cancer Active or history of blood clots (DVT, PE) Active or recent arterial thromboembolic disease (stroke, heart attack) Liver dysfunction or disease Known hypersensitivity to estradiol or any ingredients in the formulation Pregnancy This is not a complete list of precautions, contraindications, or drug interactions

Most people use it for a few weeks to a few months to get a quick jumpstart on weight loss

Ramnanan CJ, Edgerton DS, Kraft G, et al

That variability reflects factors such as starting weight, dose, adherence, and supportive habits