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By studying how the local microbiome affects immunity at remote locations and how the gut microbiota affects other organs, scientists have coined terms such as the gut-brain axis and the gut-lung axis

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Animal As a senolytic, FOXO4-DRI carries mechanism-specific theoretical risks discussed in the senescence literature including disruption of beneficial senescence surveillance and off-target effects on stem-cell populations that share features with senescent cells and senolytic translation from mouse to human has a history of failures