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This process is specifically designed by manufacturers and approved by the FDA to help the body adjust to the medication, minimize common GI side effects, and eventually reach a dose that provides maximum therapeutic benefit

A consensus of the literature suggests that when there is a dysfunction in the brain reward cascade, especially in the dopamine system, causing a low or hypo-dopaminergic trait, the brain may require dopamine individuals to avoid unpleasant feelings (8, 9)

Reads assigned to each gene were counted by featureCounts 39 (v.2.0.1) with human refseq gene sets as references for Caco-2 cells, and gene annotation of golden hamster from Ensembl database for the hamster dataset

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