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Moreover, the interaction between hyperglycemia-driven immune impairment and hypoxic niches highlights a vicious cycle for pathogen recalcitrance, yet prevalent therapies fail to account for this multifactorial etiology, requiring integrated strategies that target both microbial and host determinants for durable outcomes

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Bem indicada e bem aplicada, costuma ser bem tolerada, mas no isenta: pode haver reaes no local, reaes alrgicas e, em doses altas sem controle, efeitos indesejados