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GIP activation appears to complement GLP-1 effects synergistically rather than additively, which explains why Tirzepatide (dual agonist) produces significantly more weight loss than Semaglutide (single agonist) despite both activating GLP-1

doi: 10.3390/ijms21228499 193 BromfieldJJ

Although the specificity is higher, the sensitivity is lower than that of EIAs.1,16 The rational in accepting a test with a lower sensitivity to confirm another test with higher sensitivity was object of controversy