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on 24 patients with generalized vitiligo and 20 healthy controls found statistically significant higher levels of superoxide dismutase activity in erythrocytes, serum MDA, and nitric oxide (NO) and statistically significant lower levels of glutathione and glutathione peroxidase in the patients of vitiligo compared to the controls.[] Secondary to the oxidative stress, the polyunsaturated fatty acids undergo peroxidation resulting in formation of free radicals

The most severe variant of psoriasis is the generalized form, which is often accompanied by systemic symptoms (202)

Together, these results suggest that SIRT3 regulates epigenetic inflammatory training in HSCs