30 Three phases of colchicine poisoning include: 30 Gastrointestinal phase (10 24 hours) including abdominal pain, nausea/vomiting and diarrhoea Multiorgan phase (2 7 days) can include a wide range of serious adverse effects including paralytic ileus, myopathy, myocardial toxicity and severe cardiovascular dysfunction, respiratory failure and blood dyscrasias Recovery phase in those who survive (within a few weeks) Colchicine is contraindicated in patients with severe renal or hepatic impairment, significant gastrointestinal or cardiac conditions or pre-existing blood dyscrasias
Your doctor may recommend performing your colonoscopy under general anesthesia, meaning youll be fully asleep, or with sedation, which keeps you relaxed and drowsy, but still awake
Most patients experience their strongest side effects during weeks one through three, then notice significant improvement by week four
This efficacy suggests the drug could be suitable for patients with greater weight loss needs, including as an alternative to more invasive treatments like bariatric surgery
