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Apovian, MD, can be reached at [email protected]

Given the conflicting results, it is reasonable to speculate that the balance of STING signaling activation in different cells may influence the disease progression, such as in B cells and FLSs

In 2013, the Food and Drug Administration (FDA) required manufacturers to lower the recommended dose from 10 mg to 5 mg for immediate-release preparations and from 12.5 mg to 6.5 mg for extended-release forms

Therefore, beyond simple symptom relief, a new therapeutic paradigm is urgently required that can simultaneously control the multidimensional pathological axes of fibrotic signaling, immune imbalance, oxidative stress, and barrier disruption at an upstream level (Prow et al