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Both neurogenic inflammation and oxidative stress are key factors in migraine development, and topiramates neuroprotective potential through its anti-inflammatory and antioxidative effects is noted

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When placed in the context of the broader evidence, multiple preclinical studies indicate that NAD+ precursor supplementation can be beneficial in cancer-related contextssuch as reducing chemotherapy-induced peripheral neuropathywithout promoting tumor growth (see Table 1 for examples)

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