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The primary pathological hallmarks include the loss of dopaminergic neurons in the substantia nigra, the presence of Lewy bodies, neuroinflammation, oxidative stress, and mitochondrial dysfunction

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Graham, PhD, MD, professor of radiology with the University of Iowa Health Care, who was not involved in the research, said, While weve not encountered such issues at University of Iowa Health Care, we are anticipating that we will eventually encounter abnormal FDG PET scans as the use of GLP-1 drugs becomes more common. Graham also described how increased FDG uptake might obscure abnormal findings and reduce the accuracy of FDG PET imaging, particularly in cases of cancer