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Apelin, a cytokine produced and secreted by adipocytes, has been shown to be involved in processes such as the regulation of fluid homeostasis, food intake, cell proliferation, and angiogenesis (Zhou et al., 2018)

GLP-1 receptor agonist medications have transformed weight management for people struggling with obesity and metabolic disease

Lustig RH, Hinds PS, Ringwald-Smith K, Christensen RK, Kaste SC, Schreiber RE, Rai SN, Lensing SY, Wu S, Xiong X: Octreotide therapy of pediatric hypothalamic obesity: a double-blind placebo-controlled trial

Similarly, next-generation p38MAPK inhibitors UR-13756 and BIRB 796 inhibited IL-6 expression in human senescent fibroblasts, demonstrating their effectiveness in reducing SASP-related effects (93)