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NIX can directly bind to LC3 in the BH3 domain, recruiting phagosomes (precursors of autophagosomes) to mitochondria and acting as autophagy receptors, mediating mitochondrial clearance after mitochondrial damage and red blood cell differentiation [71]

MH patients, as well as a subset of patients with RyR1-related myopathies, carry gain-of-function mutations, whereby RyR1 has increased sensitivity to triggering ligands like caffeine and volatile anesthetics 9,35

Imaging Findings A contrast-enhanced CT neck was significant for a 3.9 1.7 1.6 cm heterogeneous, partially calcified enhancing lesion in the right carotid space, splaying the internal and external carotid