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The imidazole nitrogen of the histidine side chain donates one of the three nitrogen ligands to the copper, and the position of histidine at the second residue is what enables the deprotonated amide nitrogen of the preceding Gly-His peptide bond to also coordinate the copper

Likewise, the mentioned inability to activate the collateral pathways also resulted in harm to the failed vessels in alcohol intoxication syndrome [25], lithium intoxication syndrome [24], and isoprenaline-induced myocardial infarction syndrome [23] or maintained intra-abdominal hypertension, grade III and IV syndrome [22]

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