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The analysis on the respective cohorts was based on the following safety outcomes over 5 years from drug initiation: DKA, hypoglycaemia requiring admission to secondary care, urinary tract infection (UTI), pyelonephritis, candidiasis of the lower genital tract, acute pancreatitis and gastrointestinal upset

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The activation of PLC results in the release of inositol-1,4,5-trisphosphate (IP 3 ) from membrane associated phosphatidylinositol-4,5-bisphosphate (PIP 2 ), which then binds to specific IP 3 receptors in the endoplasmic reticulum/sarcoplasmic reticulum (ER/SR) resulting in the release of intracellular stores of Ca 2+