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Central nervous system penetration occurs through circumventricular organs (area postrema, median eminence) and peripherally expressed receptors at barrier borders, consistent with data obtained with semaglutide and tirzepatide

If sexual side effects are persistent and significantly impacting quality of life after exhausting other strategies, discussing a switch to a different medication class or a different GLP-1 agonist with your provider is reasonable

But interestingly, research has shown it may help with other issues, including epilepsy (it was originally developed to help that condition)

Given their long half-lives (i.e