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Description

Hammoud R et al

Higher drug levels mean stronger insulin secretion in response to meals, which could theoretically cause hypoglycemia

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However, glucagon itself has recently been shown to be able to stimulate insulin secretion from the perfused mouse pancreas by a mechanism which appears to involve an interaction with GLP-1 receptors (since the effect was attenuated by exendin 9-39) ( Nevertheless, when taken together, these studies do raise the possibility that pancreatic DPP-4 may be able to influence islet function by modulating the activity of locally produced GLP-1