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FIGURE 5 The Combined Deletion of slr0236 and Depletion of sll1545 Increase the Tolerance to Menadione Accompanied by a Transient Accumulation of GSH and GSSG As part of the in vivo analysis of the physiological role of the Slr0236 and Sll1545 GST, we have also tested the influence of menadione, which generates superoxide anions (O 2 ) ( slr0236 , sll1545 and slr0236-sll1545 (Figure 6A)

Before visiting the laboratory: For follow-up testing, using similar fasting conditions, collection timing, and laboratory methods may make trends easier to interpret

It is reasonable to infer that SP@M is biosafe in vivo as an intravenous medication and is promising for future application in clinics

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