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Obviously, blockade of autophagy is different to impaired autophagy and mitochondrial dysfunction since the later induces mtROS and cellular senescence also capable of inducing -SMA expression supporting fibrosis (188, 192, 196)

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16.1%) Tirzepatide was superior on all five key secondary endpoints A post-hoc cardiovascular analysis published in European Heart Journal Open (September 2025) found tirzepatide was also associated with a greater predicted 10-year cardiovascular risk reduction an absolute reduction of 2.4% vs

Nature Reviews Drug Discovery, 19 (4), 277-289