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10.1038/s41380-022-01564-0 27

Safety Profiles Side by Side Gastrointestinal Adverse Events | Event | Tirzepatide 15 mg (SURMOUNT-1) | Retatrutide 12 mg (Phase 2) | |---|---|---| | Nausea | 31% | 47% | | Vomiting | 16% | 25% | | Diarrhea | 22% | 17% | | Constipation | 19% | 13% | | Discontinuation due to GI AEs | 4.3% | 16.6% | Discontinuation rates in the retatrutide phase 2 trial were substantially higher than those seen in tirzepatide's phase 3 program, which may reflect a steeper titration schedule, the additional glucagon receptor burden, or the smaller trial population amplifying extreme responders [2][3]