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10.1016/j.bbamcr.2013.06.027 36 FalsoneS

Patients who have had IgE-mediated or nonIgE-mediated reactions to antimicrobial sulfonamides may also receive medications or other agents that contain sulfates or sulfites, such as morphine sulfate, ferrous sulfate, potassium metabisulfite and sodium bisulfite, as these are not sulfonamides

However, it is still unclear to what extent particle size and morphology influence their interaction with vascular endothelium and circulating blood cells, both in terms of potential inflammatory activation and distribution to distant organs, or how they might modulate immune cell responses [85]