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The following criteria were considered: Full economic evaluations: cost-utility analysis, cost-effectiveness analysis, cost-benefit analysis Economic evaluations reporting incremental cost-effectiveness ratios (i.e., cost per quality-adjusted life year/life years gained or cost per event avoided) Studies in patients with confirmed vitamin B12 deficiency Studies in English Abstracts were reviewed by a single reviewer and, for those studies meeting the eligibility criteria, full-text articles were obtained

Neuroprotective and Anti-Anxiety Effects via the Gut-Brain Axis Emerging data suggest oral BPC-157 may modulate the gut-brain axis , influencing neurotransmitter balance and reducing anxiety-like symptoms

153 , S68S75 (2008)

An initial consultation is required before starting BPC-157 therapy