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A method for preventing radiation-induced ototoxicity in an individual in need thereof comprising intratympanic administration of a pharmaceutical composition comprising a therapeutic agent selected from a JNK inhibitor, TRPV modulator, an MET channel inhibitor, and an otoprotectant to the individual in need thereof, wherein the pharmaceutical composition is administered prior to onset of radiation therapy, and wherein the composition provides sustained release of the therapeutic agent into the ear for a period of at least 5 days after a single administration

doi: 10.1111/ijfs.16076 122 NyanziRJoostePJBuysEM

Storage: Store Part I and Part II at 2C to 25C (36F to 77 F)

Conduct a patch test at least 24 hours before use