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Investigations Routine haematology and biochemistry, followed by endoscopy and radiology, are the principal investigations

Analysis of the large VITATOPS study, which was a cohort of 1,400 participants expanding over 10 countries, found a significant reduction (~4 mol/L) in homocysteine in the group receiving vitamin B12, folate, and vitamin B6 supplementation compared to the control (29, 30)

Advanced drug delivery systems such as solid lipid nanoparticles, liposomes, microemulsions, and micelles have also been widely used to enhance solubility and permeability of poorly absorbed compounds like BBR [21,167]