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It is used to manage alcoholic fatty liver (disease that occurs due to heavy alcohol use), liver fibrosis/cirrhosis (scarring of liver due to excessive consumption of alcohol), and hepatitis (inflammation of liver) in affected individuals

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Moreover, the findings that mice with neutrophil-specific Gpx4 haploinsufficiency recapitulate key clinical features of human SLE, including autoantibodies, neutropenia, skin lesions and proteinuria, and that the treatment with a specific ferroptosis inhibitor significantly ameliorates disease severity in lupus-prone mice reveal the role of neutrophil ferroptosis in lupus pathogenesis

Asymmetric cationolefin monocyclization by engineered squalenehopene cyclases