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Here's what "optimal" actually looks like: TSH: 0.5 - 2.0 (metabolic efficiency) Free T3: Upper third of range (active thyroid hormone) Fasting insulin: Under 5 (insulin sensitivity) Vitamin D: 60 - 80 ng/mL (immune and hormonal function) Estradiol: 150 - 250 pg/mL in perimenopause (cognitive and metabolic support) If you're operating in "normal" ranges but experiencing symptoms, you're not crazy

The results showed a consistent advantage for the combination, and that advantage became more pronounced at higher weight loss thresholds, precisely where GLP-1 therapy tends to be most clinically meaningful: At a 20% weight loss threshold, 45% of women in the combination group achieved this level of loss, compared to 24% in the GLP-1 alone group

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Hauge, M