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The crystal structure of GLP-1R NTD:GLP-1 complex (PDB ID: 3IOL) and 2AR:Gs complex (PDB ID: 3SN6) were used as initial models for NTD-hGLP-1 and Gs heterotrimer, respectively

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The effects vary significantly based on diet, lifestyle, and environmental factors

Treatment with CDDO-Me increased NRF2 expression but not to the level observed in the liver of Gclc L-KO mice, as we could only detect substantial NRF2 expression after enriching the whole protein lysate for a nuclear fraction (Fig