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CJC-1295 Stack: When to Pick One Over Both At a glance Drug class / GHRH analogs (both peptides) Sermorelin half-life / ~10-20 minutes (native-length analog) CJC-1295 without DAC half-life / ~30 minutes CJC-1295 with DAC half-life / ~6-8 days Typical sermorelin dose / 200-500 mcg subcutaneous at bedtime Typical CJC-1295 (no DAC) dose / 100-300 mcg subcutaneous, 1-3x daily Primary endpoint in stack use / serum IGF-1 normalization Evidence level / mechanistic + small RCTs

doi: 10.1016/j.chembiol.2005.02.014 65 Eisenberg-BordMSchuldinerM