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There is no clinical evidence that letrozole reduces the effectiveness of Ozempic

These male-specific impairments in glucose tolerance may reflect greater susceptibility to the metabolic programming effects of maternal diets, potentially mediated by sex-specific differences in hormones, insulin sensitivity, or central regulation of glucose metabolism

While these observational studies cannot prove causation, the consistency of the signal across different populations, healthcare systems, and analytical methods has strengthened the case for randomized trials