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Additionally, the increase of TNF- induced by TCE sensitivities in renal vascular endothelial cells inhibits the expression of SIRT1, thereby inhibiting the PINK1-Parkin mitochondrial autophagy pathway, leading to mitochondrial dysfunction and inducing apoptosis of renal vascular cells

15 Thus, as demonstrated in the current case, early detection of neurologic deficits is critical because they may be at least partially vitamin B 12 supplementation can at least partially reverse neurologic deficits

Reprod Biol Endocrinol (2013) 11(1):115