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When nebulized into a face mask, mouth piece, or tracheostomy, 1 to 10 mL of the 20% solution or 2 to 20 mL of the 10% solution may be given every 2 to 6 hours

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Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults The comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults were recently investigated in a well-conducted systematic review and network meta-analysis published by Yildiz et al [7], comprising 101 randomised controlled trials covering 20,081 study participants and 68 medications and placebo