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As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1

Bacteriostatic water is required for multi-dose vials because the 0.9% benzyl alcohol inhibits bacterial growth after the vial is punctured and exposed to airborne contaminants during syringe draws

therefore, the combination is more effective than the individual ingredients

The three main forms of human estrogen are 190 : estrone (E1), which can be synthesized by fat cells and plays a larger physiological role after menopause estradiol (E2), which is the strongest estrogen and predominates in the reproductive years estriol (E3), which is sometimes described as a weak estrogen, and circulates at low levels during the reproductive life stage, except during pregnancy when the placenta produces large amounts Over the last few decades, there has been some debate regarding the relative strength of E1, E2, and E3, particularly as it relates to their inclusion in compounded systemic hormone replacement therapy formulations