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CNS Drugs (2015) 29(9):77399

(134) found that substitutions at the 12 and 15 positions on the neurosteroid backbone altered modulation of GLIC channel activity, demonstrating the functional role of both sites

For another non-methyl B12 option, consider Seeking Health's Adeno B12. If a methylated B12 is needed, Active B12 5000 provides a combination of coenzyme forms: methylcobalamin and adenosylcobalamin