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LIGSITE: automatic and efficient detection of potential small molecule-binding sites in proteins

Particularly, negatively charged residues E144 and E151 and residues located N-terminal (N141, L142) and C-terminal (E151, L152, and N153) to the staple on 1907 were critical for activity

CREB activation is crucial not only for normal cognitive function but also for protecting against cognitive decline (Li et al., 2015)

Thus, in line with mixed findings on the potential of medication targeting ghrelin to induce changes in body weight (Gupta et al., 2021), the current body of evidence shows limited convergence for ghrelin increasing reward responses in obesity