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The proof of concept of triagonism dates back to oxyntomodulin, a natural 37-amino acid peptide produced by proglucagon cleavage in intestinal L-cells, which simultaneously activates GLP-1R and GCGR and drives marked weight loss in rodents (Cohen et al., 2003)
It is taken once daily and is being studied as a needle-free alternative to injectable GLP-1 treatments
What is Wegovy (semaglutide)
At the same time, GLP-1s are now understood to have potent anti-inflammatory effects in the brain that could reduce depression for individuals with depression related to inflammation
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