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2.1 The clinical signs The clinical signs of primary diffuse meningeal melanomatosis are very diverse: meningeal symptoms, mental disorders, and focal lesions of the cranial and spinal nerves, accompanied by peripheral paralysis and areflexia
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Many of these patients were also cigarette smokers who had unsuccessfully tried quitting before, even with the help of existing smoking-cessation medications
Such an effect could aggravate indirectly the detrimental action of oxidative stress on neurons, which is particularly enhanced in the progression of neurodegenerative diseases
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