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They are not approved to treat menopause symptoms and are not appropriate for everyone, but their mechanisms help reveal the biological links between metabolism, brain function, and the experiences many women report during this stage of life

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Methods The current study involves the fusion of a native or mutant GLP-1 (30 residues) with an HSA-binding DARPin (123 residues) via a rigid helical linker (15 residues) to create fusion proteins (168 residues) resistant to DPP-IV and, or trypsin with extended half-lives using structural modeling, which are subsequently characterized using MD simulation and molecular docking analyses

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