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Am J Physiol Regul Integr Comp Physiol (2016) 310(10):R88595

Clinical trials show an additional 0.5-1.0% HbA1c reduction when adding GLP-1 agonists to established insulin therapy

This was accompanied by hypomethylation along the X chromosome and pericentromeric regions, suggesting changes in large-scale methylation patterns due to DNMT3B deficiency alter the timing of neuronal differentiation and maturation (Martins-Taylor et al., 2012)