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Since skin steroidogenesis can be modulated by external factors and is locally restricted, there is a tremendous potential for novel topical therapeutic approaches targeting skin estrogen biosynthesis to achieve local estrogen healing benefits without off-target effects which are undesirable in both men and women, as explained in the following section

Some patients find their optimal dose at 1.0 mg, while others need the full 2.0 mg for maximum appetite suppression and metabolic benefit

Experiments were repeated three times independently, three mice per condition each time