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Differential protein expression patterns and pathway enrichment Proteins were stratified into six distinct expression categories based on their temporal patterns across four timepoints: Group 1 (consistent increase), Group 2 (consistent decrease), Group 3 (increase then decrease), Group 4 (decrease then increase), Group 5 (up-down-up), and Group 6 (down-up-down) (Fig

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If degradation is visible, discontinue use immediately.